PYROSTAR™ Neo is based on a genetically engineered approach to produce reactive factors required for endotoxin detection at pharmaceutical and medical equipment manufacturing sites. It also facilitates the same sensitivity in endotoxin detection as our limulus amebocyte lysate (LAL) reagent, PYROSTAR™ ES-F.
This reagent utilizes the Kinetic Chromogenic Assay (KCA) to measure endotoxin content. It is composed of recombinant reactive factors equivalent to Factor C, Factor B and a proclotting enzyme, which constitute the horseshoe crab’s natural endotoxin reaction system, allowing for endotoxin detection that offers the same sensitivity as the LAL reagent. In addition, the absence of factor G eliminates interference due to reaction with β-glucan, enabling improved specificity. Contact Us